August 4, 2010 David Parker
One enduring problem in transplantation immunology is the relative roles of direct (by graft APC) and indirect (by host APC) antigen presentation to the host T cells, further complicated by the ever expanding diversity of APC subsets. In this paper, the authors follow the graft and host APCs and the T cells in vivo in the skin and draining lymph nodes over time during graft rejection by 2 photon microscopy. Is seeing believing? Let's look at the movies, and then you tell me.
If you don't have access to Nature Medicine from this link, here are the pdf files.
http://pig.wikidot.com/local--files/forum:new-thread/Celli%202011.pdf
http://pig.wikidot.com/local--files/forum:new-thread/Celli%202011%20suppl.pdf
—David
